The £600,000 tournament - featuring the top 64 players on the Players Championship rankings following the conclusion of the 34-event 2025 Players Championship season - will take place at Butlin’s Minehead Resort from November 21-23.
Humphries retained the title with victory over Luke Littler 12 months ago, and the reigning champion will begin his bid for a third consecutive crown against Van Veen, in a repeat of last weekend’s European Championship final.
World number one Humphries finished the season in 58th position on the Players Championship rankings, and his reward is a showdown with seventh seed Van Veen, who has won each of the pair's three meetings in 2025.
Littler, meanwhile, will return to Minehead as the number 36 seed, and he will take on Sweden’s number one Jeffrey de Graaf, with Ross Smith or Niko Springer awaiting the winner in Round Two.
Gerwyn Price will be the top seed following his quartet of Players Championship wins across the year, and he will play Germany’s Max Hopp, who snatched the final qualification place in the 64-player field.
2025 Ladbrokes Players Championship Finals
Draw Bracket
(1) Gerwyn Price v (64) Max Hopp
(32) Rob Cross v (33) Sebastian Bialecki
(16) Martin Schindler v (49) Michael Smith
(17) Niels Zonneveld v (48) Nick Kenny
(8) Stephen Bunting v (57) Ritchie Edhouse
(25) Brendan Dolan v (40) Daryl Gurney
(9) Cameron Menzies v (56) Adam Lipscombe
(24) Bradley Brooks v (41) Martin Lukeman
(4) Ross Smith v (61) Niko Springer
(29) Jeffrey de Graaf v (36) Luke Littler
(13) William O'Connor v (52) Ricardo Pietreczko
(20) Gary Anderson v (45) Mario Vandenbogaerde
(5) Chris Dobey v (60) Keane Barry
(28) Mike De Decker v (37) Cam Crabtree
(12) Jonny Clayton v (53) James Hurrell
(21) Luke Woodhouse v (44) Alan Soutar
(2) Wessel Nijman v (63) Richard Veenstra
(31) Karel Sedlacek v (34) Nathan Aspinall
(15) Danny Noppert v (50) Ricky Evans
(18) Dirk van Duijvenbode v (47) Madars Razma
(7) Gian van Veen v (58) Luke Humphries
(26) Krzysztof Ratajski v (39) Raymond van Barneveld
(10) Josh Rock v (55) Gabriel Clemens
(23) Scott Williams v (42) Ian White
(3) Damon Heta v (62) Justin Hood
(30) Andrew Gilding v (35) Dom Taylor
(14) Joe Cullen v (51) Peter Wright
(19) James Wade v (46) Mickey Mansell
(6) Jermaine Wattimena v (59) Wesley Plaisier
(27) Dave Chisnall v (38) Ryan Joyce
(11) Ryan Searle v (54) Darren Beveridge
(22) Kevin Doets v (43) Callan Rydz